Fig. 5: Proteomics analysis identified proteins profile of DDX3X deficiency in mPFC.
From: Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity
A PcoA plot among QC, control and sh-DDX3X group. B OPLS-DA score plot between control and sh-DDX3X. C OPLS-DA validation plot (permutation = 200). D The number of up-regulated and down-regulated DEPs. E The volcano plot of DEPs. F The cluster heatmap of DEPs. G The network plot of enriched pathways based on KEGG analysis. H The z-score of ASD-related pathways based on KEGG analysis. The positive and negative z-score means the pathway is activated and inhibited, respectively. I The PPI network among LTP, glutamatergic synapse, and GABAergic synapse. J The sunburst plot of DEPs in presynapse. K The sunburst plot of DEPs in postsynapse. L The PPI network from four term based on SynGO. CTR: control, sh:sh-DDX3X.
