Fig. 1: PRISMA Flow Diagram for Study Selection.
From: A systematic review of methylome-wide associations with anxiety disorders
A Pubmed search in May 2025 yielded 799 unique articles after removal of duplicates. During abstract screening 783 articles were excluded because they were non-empirical articles, not conducted in humans, did not assess DNA methylation or did not assess it on a methylome-wide scale, or examined an outcome other than anxiety. The remaining 16 articles underwent full-text elligibility screening and 4 articles were excluded for having small sample sizes, not presenting or discussing methylome-wide association study results, or not correcting for cell-type composition. This lead to the inclusion of 12 studies in this report.
