Fig. 5: Mode of FPR2 binding to the LXA4 ligand.
From: Anti-inflammatory signaling through G protein-coupled receptors
The ligand LXA4 binds to FPR2 in a pocket near helices III, V, VI, and VII of the receptor. LXA4 penetrates into binding cavity, occupying a shallow site with the receptor transmembrane helical bundle, which differs from the binding sites for WKYMVm with FPR2. a Binding pocket of LXA4 in FPR2. The receptor in FPR2–LXA4 is marine blue in the cartoon representation. The ligand LXA4 is shown as an orange strand. b Schematic representation of interactions between FPR2 and LXA4 is analyzed using the LigPlot+ program [55]. Hydrogen bonds are shown as green dashed lines. The stick drawings of FPR2 and LXA4 are colored orange and blue, respectively. c Comparison of LXA4 ligand-binding sites in the WKYMVm-bound FPR2 structure. WKYMVm (green) and LXA4 (orange) are shown as sticks. The hydrophobic clusters that form interactions with LXA4 and FPR2 are shown in d, e purple sticks. f Polar interactions formed between LXA4 and D106, R201, and R205 in FPR2 shown as cyan sticks.
