Fig. 3: Galangin 3-methyl ether (G3-ME) supplementation restores both cardiac systolic and diastolic function in Myh6R404Q mice with pathological cardiac hypertrophy. | Acta Pharmacologica Sinica

Fig. 3: Galangin 3-methyl ether (G3-ME) supplementation restores both cardiac systolic and diastolic function in Myh6R404Q mice with pathological cardiac hypertrophy.

From: Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway

Fig. 3: Galangin 3-methyl ether (G3-ME) supplementation restores both cardiac systolic and diastolic function in Myh6R404Q mice with pathological cardiac hypertrophy.

a Schematic diagram of the mice experimental procedure. b Representative images of gross heart morphology. c The ratio of heart weight (HW) to tibial length (TL). d Representative images of echocardiograms. e The left ventricular (LV) mass. f Echocardiographic analysis of LV anterior wall (LVAW) or posterior wall (LVPW) thickness in systolic and diastolic periods. g Echocardiographic analysis of LV diameter (LVD). h Echocardiographic analysis of LV volume (LVV). i Echocardiographic analysis of LV ejection fraction. j The ratio of E peak to A peak (E/A) of mice. n = 6 per group. The values are mean ± SEM. *P < 0.05.

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