Fig. 4: Galangin 3-methyl ether (G3-ME) improves cardiac injury and remodeling in Myh6R404Q mice. | Acta Pharmacologica Sinica

Fig. 4: Galangin 3-methyl ether (G3-ME) improves cardiac injury and remodeling in Myh6R404Q mice.

From: Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway

Fig. 4: Galangin 3-methyl ether (G3-ME) improves cardiac injury and remodeling in Myh6R404Q mice.

a, b The protein expression levels of ANP and BNP in cardiac tissues. n = 4 per group. c The serum NT-proBNP levels. n = 5 per group. d, e The mRNA expression levels of Nppa, Nppb, Acta2, Col1a1, and Col3a1 in cardiac tissues. n = 4 per group. f Representative images of cardiac H&E staining. g The cardiac cross-sectional area determined by H&E staining. n = 6 per group. h Representative images of the cardiac fibrosis area using Masson’s staining. i Quantification of fibrosis area by Masson’s staining. n = 6 per group. j Representative images of cardiomyocytes by WGA staining. k Analysis of cardiomyocyte size using WGA staining from 6 mice, with all cardiomyocytes in the same area analyzed in each section. n = 375, 341, 328, 283, 353, and 340, respectively. The values are mean ± SEM. *P < 0.05.

Back to article page