Table 1 Baseline characteristics. Median and interquartile ranges, numbers, and percentages are presented.
Variable | All cohort N = 839 | Serum-MP measurable (urine-MP no measurable/unavailable) N = 440 (52.4%) | Serum & Urine-MP measurable N = 228 (27.2%) | Urine-MP measurable, only N = 171 (20.4%) | |
|---|---|---|---|---|---|
(urine-MP no measurable) N = 257/440 | |||||
Male (%) | 60.2 | 60.2 | 61.5 | 61.0 | 59.1 |
Age, y | 64 (57–70) | 64 (57–70) | 66 (57–71) | 63 (56.2–69.7) | 63 (58–71) |
Serum creatinine, mg/dL | 1.05 (0.86–1.6) | 1.0 (0.8–1.3) | 1.0 (0.8–1.3) | 1.1 (0.9–1.9) | 1.3 (0.9–2.4) |
Serum Light chain | |||||
Serum FLC measurable (involved >10 mg/dL), % | 100 | 100 | 100 | 100 | 100 |
invFLC (kappa), mg/dL | 40.4 (1.21–1.42) | 29.9 (1.60, 77.1) | 34.0 (7.04, 74.5) | 46.2 (0.98, 174) | 116 (1.14, 436) |
invFLC (lambda), mg/dL | 0.95 (0.46–46.9) | 0.88 (0.31, 18.6) | 0.89 (0.30, 11.0) | 1.16 (0.55, 106) | 0.96 (0.60, 242) |
Difference of involved-uninvolved, mg/dL | 96.8 (41.2–270) | 51.7 (23.0–111) | 48.3 (21.6–94.6) | 141 (64.8–298) | 303 (162–793) |
The ratio of involved/uninvolved | 67.7 (0.02–311) | 53.51 (0.04–205) | 64.2 (0.15–185) | 66.5 (0.01–325) | 190 (0.003–925) |
Immunoglobulins | |||||
Serum IgG | 2350 (500–4699) | 3430 (1415–5345) | 3270 (1520–5130) | 3130 (628–5280) | 515 (339–714) |
Serum IgA | 44 (18–167) | 43 (18.2– 264.7) | 50 (19–166) | 43 (17–1470) | 46 (22.7–92.5) |
Serum IgM | 15 (8–26) | 16(9–27.7) | 15 (8–28) | 13 (7–23) | 14 (8–27.5) |
Serum M-protein | |||||
Serum M-protein measurable (>1 g/dL), % | 79.6 | 100 | 100 | 100 | 0 |
Median (IQ25–75), g/dL | 2.8 (1.4–3.9) | 3.3 (2.2–4.27) | 3.0 (2.2–4.1) | 3.3 (2.2–4.6) | NA |
Urine M-protein | |||||
Urine M-protein measurable (>200 mg/24 h), % | 47.6 | 0/NA | 0 | 100 | 100 |
Median (IQ25–75), g/24 h | 0.41(0.4–1.52) | NA | NA | 0.79 (0.41–1.90) | 1.89 (0.7–3.96) |
Bone marrow plasma cells | |||||
Median, % | 50 (30–70) | 50 (30–70) | 50 (30–70) | 60 (30–80) | 50 (30–70) |
