Table 3 Multivariable analysis of factors predicting PET-2 DS 5 patient outcome.

From: Advanced stage classical Hodgkin lymphoma patients with a positive interim-PET (PET-2) Deauville score 5 after 2 ABVD cycles: a pooled analysis of three multicenter trials

Predictive Factors

PFS

OS

HR (CI 95%)

P

HR (CI 95%)

P

Age at diagnosis, median (range)

 < 45 years

  

1

 

 ≥ 45 years

  

2.76 (1.12–6.81)

0.0271

Histology

 Nodular sclerosis

  

1

 

 Other

  

1.44 (0.59–3.53)

0.4257

Leukocytes

 < 15 × 103/μL

1

 

1

 

 ≥ 15 × 103/μL

0.67 (0.43–1.04)

0.0723

0.15 (0.03–0.66)

0.0122

Lymphocytes

 ≥ 0.6 × 103/μL

1

   

 < 0.6 × 103/μL

2.93 (1.50–5.75)

0.0017

  

Monocytes

 < 0.5 × 103/μL

  

1

 

 ≥ 0.5 × 103/μL

  

0.69 (0.26–1.78)

0.4382

  1. PFS Progression-free Survival from the date of PET-2, OS Overall Survival from the date of PET-2, HR Hazard Risk, CI Confidence Interval.
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