Table 3 Contingency table of ALCpeak for IEC-neurotoxicity.

From: Clinical course, risk factors and mitigating strategies for Immune effector cell-associated late onset neurotoxicities after ciltacabtagene autoleucel CAR-T in multiple myeloma

A. Delayed Neurotoxicity

ALC peak

No Toxicity

Delayed Neurotoxicity

Total

 <3 × 109/L

99

2

101

 ≥3 × 109/L

47

21

68

 Total

146

23

169

B. Nerve Palsy

 ALC peak

No IEC-NP

IEC-NP

Total

 <3 × 109/L

100

1

101

 ≥3 × 109/L

54

14

68

 Total

154

15

169

C. Parkinsonism

 ALC peak

No IEC-PKS

IEC-PKS

Total

 <3 × 109/L

100

1

101

 ≥3 × 109/L

60

8

68

 Total

160

9

169

  1. Negative predictive value of ALCpeak <3 × 109/L = 98%.
  2. Positive predictive value of ALCpeak ≥3 × 109/L = 31%.
  3. Negative predictive value of ALCpeak <3 × 109/L = 99%.
  4. Positive predictive value of ALCpeak ≥3 × 109/L = 21%.
  5. Negative predictive value of ALCpeak <3 × 109/L = 99%.
  6. Positive predictive value of ALCpeak ≥3 × 109/L = 12%.
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