Table 3 Multivariate analysis for post-SCT overall survival in untransformed MDS (n = 199).
Variable | HR | 95% CI | p |
|---|---|---|---|
Age at SCT (per 10 years) | 0.97 | 0.82–1.16 | 0.8 |
Therapy-related MDS | 0.76 | 0.46–1.24 | 0.3 |
IPSS-R Very High risk | 1.72 | 1.06–2.79 | 0.027 |
TP53 allelic status | |||
Wild type | Ref | – | – |
Mutated monoallelic | 3.72 | 1.77–7.78 | <0.001 |
Mutated biallelic | 4.39 | 2.58–7.45 | <0.001 |
Pre-SCT therapy | |||
HMA | Ref | – | – |
Untreated | 1.68 | 0.39–7.22 | 0.5 |
Intensive chemotherapy | 0.00* | 0.00– > 9.99* | >0.9* |
Venetoclax-based | 0.58 | 0.26–1.26 | 0.2 |
HCT-CI | 1.14 | 1.03–1.27 | 0.014 |
Year of SCT | |||
2011–2016 | Ref | – | – |
2017–2023 | 0.76 | 0.40–1.45 | 0.4 |
Post-SCT cyclophosphamide | |||
No | Ref | – | – |
Yes | 0.91 | 0.50–1.67 | 0.8 |