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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
Duarte RF, Labopin M, Bader P, Basak GW, Bonini C, Chabannon C, et al. Indications for alloand auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2019. Bone Marrow Transpl. 2019;54:1525–52.
Allan DS, Keeney M, Howson-Jan K, Popma J, Weir K, Bathia M, et al. Number of viable CD34(þ) cells reinfused predicts engraftment in autologous hematopoietic stem cell transplantation. Bone Marrow Transpl. 2002;29:967–72.
Stiff PJ, Micallef I, Nademanee AP, Stadtmauer EA, Maziarz RT, Bolwell BJ, et al. Transplanted CD34(þ) cell dose is associated with long-term platelet count recovery following autologous peripheral blood stem cell transplant in patients with non-Hodgkin lymphoma or multiple myeloma. Biol Blood Marrow Transpl. 2011;17:1146–53.
Ungerstedt JS, Watz E, Uttervall K, Johansson BM, Wahlin BE, Näsman P, et al. Autologous hematopoietic stem cell transplantation in multiple myeloma and lymphoma: an analysis of factors influencing stem cell collection and hematological recovery. Med Oncol. 2012;29:2191–9.
Carlsten M, Jädersten M, Hellström A, Littmann K, Melén CM, Junlén HR, et al. The Karolinska experience of autologous stem-cell transplantation for lymphoma: a population-based study of all 433 patients 1994–2016. Exp Hematol Oncol. 2019;8:7.
Turunen A, Valtola J, Partanen A, Ropponen A, Kuittinen O, Kuitunen H, et al. Autograft cellular composition and outcome in NHL patients: results of the prospective multicenter GOA study. Leuk Lymphoma. 2020;61:2082–92.
Porrata LF, Litzow MR, Inwards DJ, Gastineau DA, Moore SB, Pineda AA, et al. Infused peripheral blood autograft absolute lymphocyte count correlates with day 15 absolute lymphocyte count and clinical outcome after autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin’s lymphoma. Bone Marrow Transpl. 2004;33:291–8.
Giralt S, Costa L, Schriber J, Dispersio J, Maziarz R, McCarty J, et al. Optimizing autologous stem cell mobilization strategies to improve patient outcomes: consensus guidelines and recommendations. Biol Blood Marrow Transpl. 2014;20:295–308.
Yang H, Acker JP, Cabuhat M, Letcher B, Larrat L, McGann LE. Association of post-thaw viable CD34 þ cells and CFU-GM with time to hematopoietic engraftment. Bone Marrow Transpl. 2005;35:881–7.
Lanza F, Saccardi R, Seghatchian J. New horizons on stem cell cryopreservation through the artificial eyes of CD34 using modern flow cytometry tools. Transfus Apher Sci. 2020;59:102785.
Acknowledgements
Statistical analysis was carried out at the statistics department of the Universitat Autònoma de Barcelona (UAB). The authors would like to thank Jesus Maroto, Silvia Tuset, and Mar Sanchez for their administrative support. We would also like to acknowledge the BST Cell Therapy Service technical team (Sonia Maroto, Maria Ruz, Yolanda Chacon, Sergio Arteaga, Marina Hortola and Camila Cardona) and the Cell Laboratory team (Javier Algar, Begoña Amill, Margarita Blanco, Ruth Forner, Daniel Navarro, Aroa Perez and Isabel Tarrago) for their work. Finally, we would like to thank all the physicians, nurses, and auxiliaries in the hematopoietic stem cell transplantation unit for their valuable contributions.
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JFS, JC, and SQ were responsible for the study design. JFS, JM, AE, MIB, ML, NGM, FVL, AG, CT, MS were involved in data collection. OV was involved in statistical analysis. JFS, JC, and SQ wrote the paper and all authors contributed to the revision of the paper.
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Fernandez-Sojo, J., Cid, J., Azqueta, C. et al. Post thawing viable CD34+ Cells dose is a better predictor of clinical outcome in lymphoma patients undergoing autologous stem cell transplantation. Bone Marrow Transplant 57, 1341–1343 (2022). https://doi.org/10.1038/s41409-022-01722-6
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DOI: https://doi.org/10.1038/s41409-022-01722-6
