Table 2 Organ dosimetry. Calculated absorbed radiation dose to critical organs expressed as mGy per infused MBq of 90Y-anti-CD66 and the mean estimated organ absorbed radiation doses in Gray (Gy) with standard deviation.

From: Efficient bone marrow irradiation and low uptake by non-haematological organs with an yttrium-90-anti-CD66 antibody prior to haematopoietic stem cell transplantation

90Y dose MBq/kg

Mean Infused Activity [90Y] MBq

Bone marrow

Liver

Spleen

Renal

Pulmonary

Whole body

mGy/MBq

Gy

mGy/MBq

Gy

mGy/MBq

Gy

mGy/MBq

Gy

mGy/MBq

Gy

mGy/MBq

Gy

5

407 ± 132

11.8 ± 1.5

4.8 ± 1.6

3.0 ± 0.8

1.2 ± 0.4

9.9 ± 4.9

3.7 ± 1.6

0.3 ± 0.1

0.1 ± 0.1

1.2 ± 1.1

0.5 ± 0.5

0.4 ± 0.1

0.2 ± 0.1

10

781 ± 171

10.3 ± 4.0

8.5 ± 1.3

2.4 ± 1.0

1.2 ± 0.3

11.0 ± 3.2

7.1 ± 3.3

0.4 ± 0.1

0.3 ± 0.1

0.4 ± 0.1

0.3 ± 0.1

0.4 ± 0.1

0.3 ± 0.0

25

1452 ± 69

10.7 ± 2.0

15.7 ± 3.5

2.4 ± 0.8

3.4 ± 1.0

8.5 ± 5.6

12.4 ± 8.2

0.5 ± 0.4

0.7 ± 0.5

1.1 ± 0.6

1.5 ± 0.9

0.4 ± 0.1

0.6 ± 0.1

37.5

2196 ± 310

11.3 ± 2.6

24.6 ± 5.6

2.7 ±1.3

5.8 ± 2.7

8.9 ± 3.9

19.1 ± 8.1

1.0 ± 0.6

2.1 ± 1.1

1.0 ± 0.5

2.2 ± 0.9

0.4 ± 0.1

0.9 ± 0.2

Overall mean mGy/MBq

 

10.1 ± 3.4

–

2.4 ± 1.1

–

9.0 ± 4.0

–

0.5 ± 0.4

–

0.7 ± 0.5

–

0.4 ± 0.1

–

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