Table 1 Patient and disease characteristics of patients who failed to achieve ANC recovery by day +30.

From: Outcomes of primary graft failure in acute myeloid leukemia patients following unrelated transplantation with post-transplant cyclophosphamide: a study from the ALWP/EBMT

Variables

Modalities

N = 141

Age at HSCT

Median (range)[IQR]

56.4 (18.2–74.1)

 

[46.2–64.3]

Patient sex

Female

54 (38.3)

Male

87 (61.7)

Year of HSCT

Median (range)[IQR]

2020 (2011–2022)

 

[2017–2021]

Median FU (y)

 −

1.1 [1–1.7]

ELN2022 cytogenetic risk

Favorable

8 (7.3)

Adverse

34 (30.9)

Intermediate

68 (61.8)

Missing

31

Disease status at HSCT

CR1

92 (65.7)

CR2

12 (8.6)

CR ≥ 3

1 (0.7)

PIF/Rel/Prog

30 (21.4)

Other

5 (3.6)

Missing

1

KPS

<90

49 (35.8)

≥90

88 (64.2)

Missing

4

Female to male

No

118 (83.7)

Yes

23 (16.3)

Donor type

UD 10/10

72 (51)

UD 9/10

48 (34)

UD 8/10

4 (2.8)

UD (missing HLA)

17 (12.1)

Patient CMV

Negative

27 (19.6)

Positive

111 (80.4)

Missing

3

Donor CMV

Negative

60 (42.9)

Positive

80 (57.1)

Missing

1

Source of cells

BM

15 (10.6)

PB

126 (89.4)

Myeloablative conditioning

No

78 (55.7)

Yes

62 (44.3)

Missing

1

In vivo TCD

No

119 (84.4)

ATG

21 (14.9)

Campath

1 (0.7)

  1. HSCT hematopoietic stem cell transplantation, IQR interquartile range, FU follow up, y years, ELN European leukemia net, CR complete remission, CR1 first CR, CR2 second CR, CR≥3 third CR or CR more advanced, KPS Karnofsky performance status, UD unrelated donor, HLA human leukocyte antigen, CMV cytomegalovirus, BM bone marrow, PB peripheral blood, TCD T cell depletion; Unless otherwise stated, results are expressed as frequencies (%).