Fig. 3: Visualisation network of the most dysregulated lipid species in CCA from the two cohorts. | British Journal of Cancer

Fig. 3: Visualisation network of the most dysregulated lipid species in CCA from the two cohorts.

From: Lipidomic profiling of human bile distinguishes cholangiocarcinoma from benign bile duct diseases with high specificity and sensitivity: a prospective descriptive study

Fig. 3

Lipid metabolism involves a complex network of interrelated pathways in which different lipid classes undergo conversions through specific enzymatic reactions. The present diagram illustrates the dysregulated lipid metabolism observed in cholangiocarcinoma (CCA) via the mapping of these metabolic pathways. Graphs showing lipidomic pathways clustered into individual lipid classes in Cohort 1 (a) and Cohort 2 (b). Differential features between two groups were identified by the p value adjusted by the false discovery rate (FDR) and fold change (FC) significance thresholds (FDR-adjusted p < 0.05, Wilcoxon rank-sum test, Benjamini‒Hochberg (BH) procedure; |log2(FC)| ≥ 1). Circles represent the detected lipid species, where the circle size expresses the significance according to -log10(FDR), whereas the colour darkness defines the degree of up/downregulation (red/blue) according to the log2(FC). The most discriminating lipids are annotated.

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