Table 2 Multivariable least square means of volumetric percent density (VPD) by tertiles of steroid hormone metabolitesa,b
From: Steroid hormone metabolites and mammographic breast density in premenopausal women
Metabolites (n = 54) | T1 LSM (95% CI) | T2 LSM (95% CI) | T3 LSM (95% CI) | P-trend | FDR P-value |
|---|---|---|---|---|---|
Sterol | |||||
Cholesterol | 8.3 (7.5–9.2) | 7.8 (7.1–8.6) | 8.5 (7.8–9.4) | 0.04 | 0.19 |
Cholesterol sulfate | 8.1 (7.4–9.0) | 8.4 (7.6–9.2) | 8.1 (7.4–9.0) | 0.94 | 0.95 |
7alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca) | 8.7 (7.9–9.6) | 8.2 (7.5–9.0) | 7.9 (7.2–8.7) | 0.05 | 0.19 |
3beta,7alpha-dihydroxy-5-cholestenoate | 8.3 (7.5–9.2) | 8.3 (7.6–9.2) | 8.1 (7.3–8.9) | 0.48 | 0.76 |
3beta-hydroxy-5-cholestenoate | 7.9 (7.1–8.7) | 8.4 (7.7–9.3) | 8.4 (7.6–9.3) | 0.19 | 0.49 |
4-cholesten-3-one | 8.4 (7.6–9.3) | 8.5 (7.7–9.4) | 7.8 (7.1–8.6) | 0.09 | 0.29 |
Campesterol | 8.3 (7.5–9.2) | 7.8 (7.1–8.6) | 8.6 (7.8–9.5) | 0.27 | 0.57 |
Pregnenolone Steroids | |||||
Pregnenolone sulfate | 7.9 (7.2–8.7) | 8.5 (7.7–9.3) | 8.3 (7.6–9.2) | 0.40 | 0.69 |
17alpha-hydroxypregnenolone 3-sulfate | 8.0 (7.3–8.9) | 8.6 (7.8–9.5) | 8.0 (7.3–8.8) | 0.64 | 0.86 |
17alpha-hydroxypregnanolone glucuronide | 8.2 (7.4–9.0) | 8.1 (7.3–8.9) | 8.4 (7.6–9.3) | 0.44 | 0.72 |
21-hydroxypregnenolone monosulfate (1) | 8.0 (7.2–8.8) | 8.3 (7.5–9.1) | 8.4 (7.7–9.3) | 0.24 | 0.52 |
21-hydroxypregnenolone disulfate | 8.3 (7.5–9.2) | 8.3 (7.5–9.1) | 8.1 (7.3–8.9) | 0.56 | 0.82 |
Pregnenediol sulfate (C21H34O5S) | 7.9 (7.1–8.7) | 8.6 (7.8–9.4) | 8.1 (7.4–8.9) | 0.75 | 0.88 |
Pregnenediol disulfate (C21H34O8S2) | 8.4 (7.6–9.3) | 8.2 (7.4–9.0) | 8.2 (7.4–9.0) | 0.64 | 0.86 |
Pregnenetriol sulfate | 8.5 (7.7–9.3) | 8.2 (7.4–9.0) | 8.1 (7.3–8.9) | 0.34 | 0.64 |
Pregnenetriol disulfate | 8.3 (7.5–9.2) | 8.5 (7.7–9.3) | 7.8 (7.1–8.6) | 0.12 | 0.36 |
Progestin Steroids | |||||
5alpha-pregnan-3beta-ol,20-one sulfate | 8.1 (7.4–9.0) | 7.7 (7.0–8.5) | 8.7 (7.9–9.6) | 0.02 | 0.14 |
5alpha-pregnan-3beta,20beta-diol monosulfate (1) | 8.1 (7.3–8.9) | 7.9 (7.2–8.7) | 8.7 (7.9–9.6) | 0.03 | 0.18 |
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) | 7.5 (6.8–8.3) | 8.2 (7.5–9.0) | 8.8 (8.0–9.7) | 4.56E-03 | 0.06 |
5alpha-pregnan-3beta,20alpha-diol disulfate | 7.9 (7.2–8.8) | 8.0 (7.3–8.8) | 8.7 (7.9–9.6) | 0.03 | 0.18 |
5alpha-pregnan-diol disulfate | 8.2 (7.4–9.1) | 7.9 (7.2–8.7) | 8.6 (7.8–9.5) | 0.09 | 0.30 |
Pregnanediol-3-glucuronide | 7.6 (6.9–8.4) | 8.4 (7.6–9.3) | 8.7 (7.9–9.6) | 0.03 | 0.17 |
Pregnanolone/allopregnanolone sulfate | 8.1 (7.3–8.9) | 7.9 (7.2–8.8) | 8.6 (7.8–9.5) | 0.08 | 0.29 |
Corticosteroids | |||||
Corticosterone | 8.3 (7.5–9.1) | 8.2 (7.4–9.0) | 8.3 (7.5–9.2) | 0.82 | 0.88 |
Cortisol | 8.3 (7.5–9.1) | 8.1 (7.4–8.9) | 8.4 (7.6–9.2) | 0.77 | 0.88 |
Tetrahydrocortisol glucuronide | 8.5 (7.7–9.4) | 8.4 (7.6–9.3) | 7.7 (6.9–8.5) | 0.02 | 0.14 |
Tetrahydrocortisol sulfate (1) | 8.0 (7.3–8.8) | 8.2 (7.4–9.0) | 8.5 (7.7–9.4) | 0.18 | 0.47 |
Cortisone | 8.1 (7.3–8.9) | 8.0 (7.3–8.9) | 8.5 (7.7–9.3) | 0.30 | 0.61 |
Tetrahydrocortisone glucuronide (5) | 8.4 (7.7–9.3) | 8.6 (7.8–9.4) | 7.5 (6.8–8.3) | 4.75E-03 | 0.06 |
Cortolone glucuronide (1) | 8.9 (8.1–9.8) | 8.3 (7.6–9.2) | 7.3 (6.6–8.1) | 7.55E-05 | 0.01 |
Androgenic Steroids | |||||
11-ketoetiocholanolone glucuronide | 8.3 (7.5–9.1) | 8.1 (7.3–8.9) | 8.4 (7.6–9.3) | 0.66 | 0.86 |
Dehydroepiandrosterone sulfate (DHEA-S) | 8.3 (7.5–9.2) | 8.4 (7.6–9.3) | 8.1 (7.4–8.9) | 0.51 | 0.78 |
16alpha-hydroxy DHEA 3-sulfate | 8.2 (7.5–9.1) | 8.2 (7.4–9.0) | 8.3 (7.5–9.1) | 0.83 | 0.88 |
Androsterone glucuronide | 8.8 (8.0–9.7) | 7.8 (7.1–8.6) | 8.1 (7.3–8.9) | 0.17 | 0.45 |
Epiandrosterone sulfate | 8.3 (7.5–9.2) | 8.1 (7.3–8.9) | 8.4 (7.6–9.2) | 0.76 | 0.88 |
Androsterone sulfate | 8.3 (7.5–9.2) | 8.1 (7.4–9.0) | 8.3 (7.5–9.1) | 0.99 | 0.99 |
Etiocholanolone glucuronide | 8.6 (7.8–9.4) | 8.1 (7.4–8.9) | 8.1 (7.3–8.9) | 0.27 | 0.57 |
11beta-hydroxyetiocholanolone glucuronide | 8.2 (7.5–9.0) | 8.1 (7.3–8.9) | 8.4 (7.6–9.3) | 0.43 | 0.72 |
5alpha-androstan-3alpha,17alpha-diol monosulfate | 8.2 (7.4–9.0) | 8.2 (7.4–9.0) | 8.3 (7.5–9.2) | 0.76 | 0.88 |
Androstenediol (3beta,17beta) monosulfate (1) | 8.9 (8.1–9.9) | 8.2 (7.4–9.0) | 7.8 (7.1–8.6) | 0.01 | 0.12 |
Androstenediol (3beta,17beta) monosulfate (2) | 8.8 (7.9–9.7) | 8.6 (7.8–9.4) | 7.5 (6.9–8.3) | 8.89E-04 | 0.03 |
Androstenediol (3beta,17beta) disulfate (1) | 9.0 (8.1–9.9) | 8.4 (7.6–9.3) | 7.6 (6.9–8.4) | 8.41E-04 | 0.03 |
Androstenediol (3beta,17beta) disulfate (2) | 8.6 (7.8–9.5) | 8.1 (7.4–8.9) | 8.0 (7.3–8.8) | 0.13 | 0.39 |
Androstenediol (3alpha, 17alpha) monosulfate (2) | 8.5 (7.7–9.3) | 8.0 (7.3–8.9) | 8.2 (7.4–9.0) | 0.56 | 0.82 |
Androstenediol (3alpha, 17alpha) monosulfate (3) | 8.4 (7.6–9.3) | 8.4 (7.6–9.2) | 7.9 (7.2–8.7) | 0.15 | 0.40 |
5alpha-androstan-3alpha,17beta-diol monosulfate (1) | 8.5 (7.7–9.4) | 8.6 (7.8–9.5) | 7.7 (6.9–8.4) | 0.01 | 0.14 |
5alpha-androstan-3alpha,17beta-diol monosulfate (2) | 8.6 (7.8–9.5) | 8.8 (8.0–9.7) | 7.5 (6.8–8.2) | 3.24E-04 | 0.02 |
5alpha-androstan-3alpha,17beta-diol disulfate | 8.6 (7.8–9.5) | 8.5 (7.8–9.4) | 7.6 (6.9–8.4) | 2.20E-03 | 0.05 |
5alpha-androstan-3beta,17beta-diol monosulfate (2) | 8.6 (7.8–9.4) | 8.5 (7.6–9.4) | 7.9 (7.1–8.6) | 0.05 | 0.19 |
5alpha-androstan-3beta,17beta-diol disulfate | 8.8 (7.9–9.7) | 8.3 (7.5–9.2) | 7.8 (7.1–8.6) | 0.02 | 0.14 |
5alpha-androstan-3beta,17alpha-diol disulfate | 8.1 (7.3–8.9) | 8.2 (7.5–9.1) | 8.4 (7.6–9.3) | 0.33 | 0.64 |
Andro steroid monosulfate C19H28O6S (1) | 8.1 (7.3–9.0) | 8.3 (7.6–9.2) | 8.2 (7.5–9.1) | 0.77 | 0.88 |
11beta-hydroxyandrosterone glucuronide | 8.6 (7.8–9.5) | 8.4 (7.6–9.2) | 7.7 (7.0–8.5) | 0.02 | 0.14 |
Estrogenic Steroids | |||||
Estrone 3-sulfate | 8.5 (7.7–9.4) | 8.0 (7.3–8.9) | 8.1 (7.3–8.9) | 0.34 | 0.64 |
