Fig. 6: Representative illustrations of a dedicated 6-plex multiplex immunohistochemistry (mIHC) in No_NAT and FFX + SBRT samples (n = 4). | British Journal of Cancer

Fig. 6: Representative illustrations of a dedicated 6-plex multiplex immunohistochemistry (mIHC) in No_NAT and FFX + SBRT samples (n = 4).

From: Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX followed by high-dose stereotactic body radiotherapy

Fig. 6

Representative images of: a Global immune infiltration in No_NAT group with high density of tumoral glands; b Global immune infiltration in FFX + SBRT group with less density of tumoral glands; c Global distribution of tumour infiltrating lymphocytes (TILs) in No_NAT group; d TILs in FFX + SBRT group are not sequestrated within the collagenous area; e TILs in No-NAT group close to the tumoral glands; f TILs in FFX + SBRT group are mainly located close and in direct with the tumoral glands; CD4+, CD8+ and CD20+ was observed within the tumoral glands. Cell swelling and pyknotic nucleus of the tumoral cells can be observed in FFX + SBRT treated PDAC; g Tumour associated macrophages (TAMs) and CCR2+ cells populations in No_NAT group; h TAMs are frequently observed within the lumen of tumoral glands in FFX + SBRT group and CCR2+ cells expression is maintained. No_NAT no neoadjuvant treatment group, FFX FOLFIRINOX, SBRT stereotactic body radiotherapy.

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