Fig. 4: Anti-PD-1 therapy alter transcriptomes.
From: PD-1 inhibitor improves radiosensitivity by tumor vessel normalization
a PCA of transcriptional profiles in tumor samples treated with or without anti-PD-1 inhibitors, calculated based on top 1% most variable genes. b Dotplot representation of selected significant pathways from GOBP databases on DEGs in isotype treated vs. anti-PD-1 inhibitor treated tumors (ORA, cut-off: P. adj<0.05). c Heatmap of selected DEGs in isotype treated vs. anti-PD-1 inhibitor treated tumors. d Dotplot representation of selected significant pathways from GSEA vs. Hallmark and GOBP databases. GSEA computed by comparing isotype treated vs. anti-PD-1 inhibitor treated tumors (cut-off: P. adj<0.05). e Heatmap of hypoxia scores (Seigneuric gene, Buffa gene, Winter gene, West gene, Ragnum gene), Tian anagenesis scores and Tip-like cell scores in tumor samples treated with or without anti-PD-1 inhibitors.
