Table 1 Loss of FLVCR1a in endothelial cells leads to embryonic death
From: Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis
Embryonic stage | N | Flvcr1aflox/+ | Flvcr1aflox/+ Tie2Cre | Flvcr1aflox/flox | Flvcr1aflox/flox Tie2cre |
|---|---|---|---|---|---|
11.5–12.5 | 57 | 10 (17.5%) | 14 (24.5%) | 13 (22.8%) | 20 (35%) |
13.5 | 190 | 32 (16.8%) | 56 (29.5%) | 56 (29.5%) | 46 (24,2%) |
14.5 | 28 | 8 (28.6%) | 7 (25%) | 6 (21.4%) | 7 (25%) |
Newborns | 46 | 13 (28.2%) | 17 (36.9%) | 16 (34.7%) | 0 (0%) |
