Fig. 3 | Cell Death & Differentiation

Fig. 3

From: Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity

Fig. 3

Analyses of glial reactivity resulting from MPTP intoxication in control and astrocytic GR mutant mice. a Immunohistochemical staining with anti–Iba-1 antibody in SN 3 days after MPTP treatment shows increased microglial activation in the GRCx30CreERT2 mutants. Scale bar, 50 μm. b, c Quantification of surface area (s.a) and density (right) of Iba-1 + microglia in SN (b) and striatum (ST) (c) of controls mice and GRCx30CreERT2 mutants 3 and 7 days after saline or MPTP injection. **p < 0.01; *p < 0,05 controls vs mutants, post-hoc Bonferroni/Dunn test. #p < 0.05; ##p < 0.01; ##p < 0.01saline vs MPTP. d, e Quantification of surface area (s.a) and density (right) of GFAP + astrocytes in SN (d) and striatum (e) in control mice and GRCx30CreERT2 mutants 3 and 7 days after saline or MPTP injection. #p < 0.05 saline vs MPTP. In all, error bars represent SEM. n = 5 mice/group

Back to article page