Fig. 8 | Cell Death & Differentiation

Fig. 8

From: Uric acid: a potent molecular contributor to pluripotent stem cell cardiac differentiation via mesoderm specification

Fig. 8

a Zygote is the beginning of embryonic differentiation. ESC in vitro comes from inner cell mass (ICM), which would development into gastrula with pluripotency gradually declined. Differentiation of ESC/iPSCs generates mesodermal characterized cells, including mesoderm progenitor and mesoderm. Epithelial–mesenchymal transition takes place in the development of gastrula. b ① Within 24 h UA could stimulate WNT pathway to increase beta- catenin and then promote EMT, downregulated E-cadherin and upregulated vimentin. ② UA could increase degradation of cyclinD1 in 48 h, which could decrease the expression of cyclinD1 and then lengthen G0/G1 phage. G0/G1 phage lengthened promoted differentiation

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