Fig. 8
From: The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation
Scheme of the proposed mechanism of HOTAIR regulation. a In EMT cells HNF4α is negatively regulated and HOTAIR expression positively controlled by the enhancer. b In epithelial cells HNF4α represses HOTAIR transcription by interfering with the formation of a regulatory chromatin loop
