Fig. 3 | Cell Death & Differentiation

Fig. 3

From: Reprogramming miRNAs global expression orchestrates development of drug resistance in BRAF mutated melanoma

Fig. 3

Shared deregulated miRNAs of drug-resistant melanoma cells act on cell intrinsic pathways. a FACS analysis showing that the overexpression of both miR-204-5p and miR-199b-5p induce M14S and WM266S cell apoptosis. b TCGA Skin Cutaneous Melanoma data revealing high co-expression of miR-204-5p/miR-199b-5p associated with a better survival probability (p = 0.0236). c Transient overexpression of miR-204-5p in M14S cells affecting Bcl-2 expression at mRNA (left panel) and protein (right panel) levels. d Enforced expression of miR-199b-5p reducing VEGFA and HIF-1α expression levels in M14S (left panel) and WM266S (right panel). e Venn Diagrams revealing the commonly deregulated target mRNAs of miR-4443 and miR-4488. f miR-4443 and miR-4488 overexpression reducing PTPN14 mRNA in M14S cells. g miR-4443 but not miR-4488 overexpression affecting TIMP2 mRNA in M14S cells

Back to article page