Fig. 4 | Cell Death & Differentiation

Fig. 4

From: Reprogramming miRNAs global expression orchestrates development of drug resistance in BRAF mutated melanoma

Fig. 4

Simultaneous cotargeting of deregulated miRNAs affects drug-resistant melanoma cell growth. a Different miRNA action on non-redundant pathways relevant for melanoma progression. b–g miR-204-5p + miR199b-5p (b), amiR-4443 + amiR-4488 (c), miR-204-5p + amiR-4443 (d), miR-204-5p + amiR-4488 (e), miR-199b-5p + amiR-4443 (f) and miR-199b-5p + amiR-4488 (g) strongly reducing M14R cell colony formation as compared to single treatments. h Co-expression of miR-204-5p and miR-199b-5p mimics affecting A375DR cell colony formation as compared to single treatments (left panel) and even further when combined with miR-579-3p (right panel)

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