Fig. 2
From: T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate
Bimhi cells bias to pre-memory cells, promote TCM cells and maintain Bim levels. a Numbers of transferred P14-Bim-mCherry reporter cells harvested on 11 dpi (1 day after transfer, n = 4) or 24 dpi (14 days after transfer, n = 4). Bar graph (mean ± SD) compares mice receiving Bim-mCherryhi cells (black bars) or mice receiving Bim-mCherrylo cells (white bars). Cell number fold differences are shown above horizontal lines. b Bar graphs (mean ± SD) show frequencies of terminal effector cells, pre-memory cells, or c TCM cells among transferred Bimhi (black bars) or Bimlo (white bars) P14 cells on 24 dpi (n = 4). d Representative histograms of Bim-mCherry fluorescent intensities gated on transferred Bimhi or Bimlo cells harvested on 11 dpi (n = 3) or 24 dpi (n = 4). Bimhi frequencies and MFI (mean ± SD) are shown. All experiments were performed twice with similar results. For all panels, *p < 0.05 (unpaired two-tailed Student’s t-test)
