Fig. 1
From: LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice
Dynamic expression of LanCL1 in the spinal cord of ALS mice. a Diagram depicting the definition of pathological stages of the SOD1G93A mouse model of ALS. b Quantitative mRNA levels of LanCL1 in the lumbar spinal cord (L3–L5) of WT and SOD1G93A mice at presymptomatic stage (P30 and P75), early-symptomatic stage (P120) and late-symptomatic stage (P150). Data represent mean ± SEM, n = 4 mice per genotype per timepoint, ***p < 0.001, n.s. nonsignificant, two-way ANOVA followed by Bonferroni post hoc test. Immunoblots (c) and quantifications (d) of LanCL1 in the lumbar spinal cord (L3–L5) of WT and SOD1G93A mice at presymptomatic stage (P30 and P75), early-symptomatic stage (P120) and late-symptomatic stage (P150). Data represent mean ± SEM, n = 3 mice per genotype per timepoint, *p < 0.05, ***p < 0.001, n.s. nonsignificant, two-way ANOVA followed by Bonferroni post hoc test
