Fig. 5: BCAT2 regulates ferroptotic cell death in cancer cells.
From: Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells
Ferroptosis inducers(erastin, sorafenib, or sulfasalazine) activate ferritinophagy and AMPK phosphorylation, which consequently suppresses nuclear translocation of SREBP1, and inhibits the transcription of its direct target gene BCAT2. BCAT2 is a suppressor of ferroptosis by regulating intracellular glutamate levels.
