Fig. 1: The ubiquitin system and families of E3 ubiquitin ligases.
From: The role of E3 ubiquitin ligases in the development and progression of glioblastoma
a Ubiquitin is ligated to proteins via a cascade involving E1, E2 and E3 ubiquitin ligases. E3s attach ubiquitin via specific lysine residues, which determine protein fate following ubiquitin conjugation. Ligation is carried out by a family of four distinct E3 ligases (b).
