Table 1 Modulation of receptor tyrosine kinase signalling by E3 ligases.

CBL

EGFR

EGFR signalling

[10, 13,14,15, 19,20,21,22, 25]

CHIP

EGFR

EGFR signalling

[31, 32]

KBTBD7

NF1

MAPK

[64]

LZTR1

RAS

MAPK

[51,52,53,54]

NEDD4-1

PTEN

PI3K-AKT

[44, 45, 56]

PARK2

EGFR, PKM2

EGFR signalling/PI3K-AKT

[27, 28, 42]

PRAJA1

CIC

EGFR signalling MAPK

[163]

SCF^βTrCP

PHLPP1

PI3K-AKT

[35, 37]

SCF^FBXO31

MKK6

MAPK

[67]

SCF^SKP2

P27^Kip1

Cell cycle

[47, 48]

TRAF6

Akt

PI3K-AKT

[39, 40]

TRIM9_(S)

MKK6

MAPK

[68]

TRIM11

–

EGFR signalling

[29]

TRIM21

PFKP

PI3K-AKT

[43]