Table 2 E3 ligase-dependent modulation of glioblastoma stem cells.

BMI1

Histone 2A (lysine 119)

–

[73,74,75, 77, 78, 82,83,84, 86]

CDC20/APC

SOX2 stabilisation

Stem cell maintenance

[104]

Cul3

Dvl2, GLI2

SHH/Wnt

[89]

HUWE1

N-Myc

–

[99]

RNF19A

–

–

[106]

RNF144A

BMI1

–

[77, 78]

RNF41

Dvl2

SHH

[90]

SCF^βTrCP

REST

Neural stem cell maintenance

[92,93,94, 96]

SCF^FBXL14

Myc

–

[97]

TRIM8

PIAS1

STAT signalling

[101, 102]