Table 3 E3 ubiquitin ligase-dependent regulation of cell death in glioblastoma.
From: The role of E3 ubiquitin ligases in the development and progression of glioblastoma
E3 ligase | Substrate/Downstream effector | Pathway | Reference(s) |
|---|---|---|---|
A20 | RIPK1 | TNF-α signalling, EGFR signalling, death receptor-mediated apoptosis, stem cell maintenance | |
BIRC2 | RIPK1 | TNF-α signalling | |
BIRC3 | RIPK1 | TNF-α signalling | |
Cul3 | BCL-2 | Intrinsic apoptosis | [154] |
HOIP | – | TNF-α signalling | [119] |
ITCH | FLIP(S) | Death receptor-mediated apoptosis | |
Mdm2 | p53 | Intrinsic apoptosis | |
RNF138 | rpS3 | DNA damage repair/apoptosis | [153] |
RNF168 | H2AX | DNA damage repair | |
SMURF2 | H2AX | DNA damage repair | [150] |
TRAF2 | – | TNF-α signalling, EGFR signalling, death receptor-mediated apoptosis | |
XIAP | Caspase 3/7/9, survivin | Intrinsic apoptosis |
