Fig. 6: CTPI-2 regulates the citrate concentration in the liver and blunts triglyceride production. | Cell Death & Differentiation

Fig. 6: CTPI-2 regulates the citrate concentration in the liver and blunts triglyceride production.

From: Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH

Fig. 6

a, b Citrate and Ac-CoA levels derived from liver extracts of HFD+vehicle (grey) or HFD+CTPI-2 (red). c, d Levels of the indicated triacylglycerides (TAG, panel c) and total fatty acids (FA, panel d) detected with the Lipidyzer platform. N = 2–3 mice per group. e, f Levels of the indicated metabolites detected with targeted LC-MS analysis. g HepG2 cells were treated with CTPI-2 for 5 h, in the presence or absence of 5 mM sodium citrate. The indicated mRNA levels were analyzed with RT-qPCR. h Model summarizing our findings (see also text for explanation). Bars indicate standard deviations. *p ≤ 0.05, **p ≤ 0.01, ***p ≤0.001.

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