Fig. 1: LY3039478 inhibits NOTCH1 and HES1 in iCCA experimental models. | Cell Death & Differentiation

Fig. 1: LY3039478 inhibits NOTCH1 and HES1 in iCCA experimental models.

From: Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis

Fig. 1

Western blot analysis demonstrates inhibition of NOTCH1 and HES1 on five iCCA cell lines treated for 24 and 48 h with LY3039478 even at low concentrations. Data are representative of three independent experiments. Histograms represent the mean ± SEM. *P < 0.05; **P < 0.01, ***P < 0.001 compared with treatment with vehicle (CTRL).

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