Fig. 7: Schematic representation of the molecular pathway leading to cell death on AICD. | Cell Death & Differentiation

Fig. 7: Schematic representation of the molecular pathway leading to cell death on AICD.

From: JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction

Fig. 7: Schematic representation of the molecular pathway leading to cell death on AICD.

Diagram illustrating the molecular events occurring after TCR engagement and leading to AICD induction. Upon TCR triggering, both JNK1 and ERK1/2 are phosphorylated and activated. ERK1/2 sustains JNK1 activation and promotes the upregulation of Bim isoforms L and S. In turn, Bim activates the protease OMA1, which cleaves Opa-1 oligomers, promoting cristae disassembly. Together, JNK1 and ERK1/2 phosphorylate Drp1 on Ser616, promoting its activation. Active Drp1 fragments mitochondria, which is a prerequisite to mediate the Mitochondrial Outer Membrane Permeabilization (MOMP) in combination with Bim. Cristae disassembly and MOMP promote cytochrome-C release in the cytosol, leading to cell death by activating caspases.

Back to article page