Fig. 3: REGγ deficiency improves cardiac oxidative stress in response to hypertrophic stimuli.
From: The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα–SOD2 pathway
a REGγ deficiency inhibits cardiac ROS accumulation (scale bars: 50 μm) and b corresponding quantitation graphs of DHE relative fluorescence in mice after TAC operation for 4 weeks by DHE staining analysis (n = 10 for each genotype; *** P < 0.001, one-way ANOVA test). REGγ knockdown inhibits ROS accumulation (scale bars: 40 μm) and corresponding quantitation bar graphs of DHE relative fluorescence in (c, d) NRCMs and (e, f) human cardiomyocyte AC16 cells after Ang II treatment by DHE staining analysis. (The experiments were repeated three times; error bars represent standard deviation, **P < 0.01, ***P < 0.001, one-way ANOVA test).
