Fig. 1: Expression patterns of SIX1 in developing female reproductive tract.
From: SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Müllerian duct epithelium
a Volcano plot displaying differential expressed genes in mouse PD2 uterus and vagina. Genes significantly enriched in vagina and uterus in microarray analysis [16] are marked in red and green, respectively. b Immunoblot analysis of SIX1 and RUNX1 expression in PD2 mouse FRT and ovary. The vagina was divided into upper and lower half. Immunofluorescence assay for RUNX1, SIX1 (green) and TRP63 (red) in the lower FRT at PD1 (c) and PD2 (d, e). Outer wall of fornix is marker with dotted line (d). In the vaginal fornix (e), RUNX1 is downregulated in MDE upon expression of TRP63 (white arrows), whereas TRP63 and SIX1 are co-expressed (yellow arrows). Bar = 100 µm (c, d), =50 µm (e).
