Fig. 5: The expression of genes involved in chromosome attachments is altered in EAC tumors. | Cell Death & Differentiation

Fig. 5: The expression of genes involved in chromosome attachments is altered in EAC tumors.

From: Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments

Fig. 5

a Graphs illustrating expression levels measured in log-transformed Transcripts Per Million (TPM) for genes PPP1R1B, DSN1, and MAD2L1BP across EAC cases with different alteration types showing significant increase in expression upon amplification as compared to control wild type (WT) cases. (p values computed through Wilcoxon test). b RNA-seq based single sample geneset enrichment analysis of annotated gene signatures across EAC cases (n = 145) shows co-enrichment of our kinetochore gene signature (Supplementary Table S5) with known cell-cycle hallmark gene signature [49].

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