Fig. 2: Identification of phylogenetic conserved putative regulatory sites and the transcription start in the MKI67 gene.
From: Ki-67 gene expression
A DNA segment spanning ~0.6 kb upstream from the first MKI67 intron of the human gene (genome version hg38) and surrounding the transcriptional start site (TSS) was aligned to 100 vertebrate genes using the UCSC Genome Browser. The most conserved region of about 100 nucleotides is displayed in detail giving a sequence alignment of the human, chimpanzee, marmoset, mouse, and elephant gene regions. Transcriptional elements are highlighted and named relative to their position to the MKI67 coding region: CCAAT-boxes (CCAAT1, 2, and 3), proximal cell cycle genes homology region CHR (CHRprox), cell cycle-dependent element (CDE), and distal CHR (CHRdist).
