Fig. 1: Patients’ KRAS-amplified tumours express high levels of YB-1 and associated stress response genes. | Cell Death & Differentiation

Fig. 1: Patients’ KRAS-amplified tumours express high levels of YB-1 and associated stress response genes.

From: De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer

Fig. 1

A YB-1 mRNA levels compared to KRAS copy number status in invasive breast carcinoma samples in the TCGA dataset. Values for YB-1 are shown as Reads Per Kilobase of transcript, per Million mapped reads (RPKMs). B YB-1 mRNA levels compared to KRAS copy number status in invasive breast carcinoma samples in the METABRIC dataset. Values for YB-1 are shown as RPKMs. C HIF1A (left panel) CAIX (middle panel) and G3BP1 (right panel) mRNA expression according to KRAS copy number status in invasive breast carcinomas in TCGA dataset. Values for HIF1A, CAIX and G3BP1 are shown as RPKMs. D Scatter plot of YB-1 and G3BP1 mRNA expression in amplified-KRAS invasive breast carcinomas. E YB-1 (left panel) HIF1A (middle panel) and G3BP1 (right panel) mRNA expression according to AKT1 copy number status in invasive breast carcinomas in METABRIC dataset. Values for YB-1, HIF1A and CAIX are shown as RPKMs. F Scatter plot of YBX1 and G3BP1 mRNA expression in amplified-AKT1 invasive breast carcinomas. P-values in panels (A, C, D) were determined by Student’s t test, *P < 0.05, **P < 0.01, ***P < 0.001.

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