Table 2 Main clinical data of: (A) patients for IHC analysis of lung autopsy, (B) COVID-19 patients for IHC analysis of lung autopsy, and (C) patients for molecular, phenotypic, and functional data.
From: Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis
NRD | BP | COVID-19 | |
|---|---|---|---|
(A) Main clinical data of patients for IHC analysis of lung autopsy | |||
Parameters | N = 4 | N = 4 | N = 23 |
Age (year), median (range) | 64.5 (48–80) | 63 (44–82) | 82 (54–95) |
Gender, n (%) | |||
Males | 2 (50%) | 4 (100%) | 11 (48%) |
Females | 2 (50%) | 12 (52%) | |
Co-morbidity, n (%) | |||
Absent | 0 | 1 (25%) | 3 (13%) |
1 | 1 (25%) | 2 (50%) | 8 (34.8%) |
2 | 0 | 1 (25%) | 8 (34.8%) |
3 | 3 (75%) | 0 | 4 (17.4%) |
(B) Main clinical data of COVID-19 patients for IHC analysis of lung autopsy | |||
c-FLIP−CD68−pSTAT3− | c-FLIP+CD68+pSTAT3+ | ||
Days of hospitalization, median (range) | 25 (11–52); N = 10 | 18 (0–32); N = 13 | |
CRP (mg/L), median (range) | 75.79 (9–271.2); N = 10 | 80.83 (5.92–242.5); N = 12 | |
Pro-calcitonin (ng/mL), median (range) | 2.12 (0.14–9.45); N = 9 | 0.81 (0.2–9.45); N = 10 | |
(C) Main clinical data of patients for molecular, phenotypic, and functional data | |||
Healthy controls | Mild patients | Severe patients | |
Characteristics | N = 4 | N = 11 | N = 14 |
Anagraphic | |||
Age, Yr: Median (IQR) | 66 (64–73) | 71 (63–86) | 70 (60–71) |
Male, no. (%) | 3 (75) | 10 (90.9) | 6 (85.7) |
Clinical features at sampling | |||
APACHE score, median (IQR) | – | – | 25 (13.5–28) |
SOFA score, median (IQR) | – | – | 7 (4–8) |
Score on ordinal scale (1–8), median (IQR) | – | 4 (3–4) | 5 (3–7) |
