Fig. 4: Bone resorption is promoted in Ddr2Adipo mice.
From: Targeting adipocytic discoidin domain receptor 2 impedes fat gain while increasing bone mass
A TRAP staining of femurs of 3-month-old Ddr2Adipo and WT littermates. Histomorphometric analysis of osteoclast number per bone surface (OC. No./BS) and osteoclast surface per bone surface (OC. S/BS) of Ddr2Adipo and WT femurs. n = 5 femurs from 5 mice for each group. Scale Bar = 100 μm. B Serum TRAP5b of Ddr2Adipo and WT mice. n = 6/group. C mRNA expression of osteoclast differentiation markers in femurs of 4-week-old Ddr2Adipo and WT mice. n = 6/group. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01 as determined by unpaired t-test.
