Fig. 4: Synergistic effect of select compounds with remdesivir using SARS-CoV-2 viral infection assay.
From: The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target
Representative graphs are shown of the antiviral activity (full symbols) and cytotoxicity (empty symbols) of compounds #79, #96 and #102 in A549+ACE2 cells infected with SARS-CoV-2. Compounds were applied at the following concentrations: #79: 60 μM, #96: 15 μM, #102: 25 μM. Remdesivir concentrations are indicated on the X-axis in μM. Error bars represents SEM. IF images of representative wells show anti-N staining (red) and DAPI signal (blue) at indicated drug concentrations. Graph shows the EC50 values from three independent experiments using technical triplicates. Error bars represents SEM.
