Fig. 2: SARS-CoV-2 triggered IL-1β, IL-18 and M65 release in COVID-19 patients.
From: SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1
Quantification of serum IL-1β (A) and IL-18 (B) levels in COVID-19 patients with mild-to-moderate and severe disease. C Correlation between serum levels of IL-1β and IL-18 (n = 91). D Log2 serum M65 levels in heathy subjects and COVID-19 patients with different disease severity. E Correlation between serum log2 M65 (n = 78) and IL-1β. F Kaplan–Meier estimate of the requirement of the oxygen therapy by serum M65 levels. Dashed lines indicate 95% confidence intervals. Significance was assessed using Wilcoxon log-rank (A, B) or Kruskal–Wallis with Wilcox log-rank test (D). Significance and correlation coefficient were assessed using Spearman’s correlation test with 95% confidence interval (C, E). Box plots with outliners and points representing individual sample were shown.
