Fig. 4: BRD4 inhibitors repress STING expression and STING-mediated NFκB activation. | Cell Death & Differentiation

Fig. 4: BRD4 inhibitors repress STING expression and STING-mediated NFκB activation.

From: Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration

Fig. 4

A Schematic diagram shows drug screening process. The red triangles represent identified BRD4 inhibitors. B Representative images from high-content analysis. Arrow heads: γH2Ax-positive cytosolic DNA. Right panel: relative cytosolic DNA number after normalized to nuclei numbers, 30–50 cells counted. WB or qRT-PCR analysis showing protein C or gene D expression in ARPE-19 cells. Selection of other small molecules in WB was based on results from high-content analysis. Treatment conducted as described in A. WB E or qRT-PCR F analysis conducted in 661W treated with or without 10 μM of JQ1 for 24 h.

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