Table 1 Examples of miRNAs implicated in ferroptosis regulation in cancer.
From: Non-coding RNAs and ferroptosis: potential implications for cancer therapy
miRNA | Role in ferroptosis | Mechanism of action | Reference |
|---|---|---|---|
miR-375 | Induces ferroptosis in gastric cancer | Downregulates SLC7A11 | [34] |
miR-4715-3p | Induces ferroptosis in gastric and esophageal carcinomas | Downregulates AURKA and GPX4 expression | [170] |
miR-214-3p | Induces ferroptosis in HCC | Downregulates ATF4 and SLC7A11 | [35] |
miR-101-3p | Induces ferroptosis in lung cancer | Downregulates TBLR1, NF-κB, GPX4 and PTGS2 expression | [26] |
miR-324-3p | Induces ferroptosis in LUAD | Downregulates GPX4 | [27] |
miR-324-3p | Induces ferroptosis in breast cancer | Downregulates GPX4 | [28] |
miR-5096 | Induces ferroptosis in breast cancer | Downregulates SLC7A11 | [36] |
miR-1287-5p | Induces ferroptosis in osteosarcoma | Downregulates GPX4 | [171] |
miR-137 | Inhibits ferroptosis in melanoma | Downregulates SLC1A5 | [93] |
miR-9 | Inhibits ferroptosis in melanoma | Downregulates GOT1, inhibits glutaminolysis | [172] |
miR-130b-3p | Inhibits ferroptosis in melanoma | Downregulates DKK1, upregulates NRF2 and HO-1 expression | [173] |
miR-103a-3p | Inhibits ferroptosis in gastric cancer | Downregulates GLS2, prevents hydrolysis of glutamine to glutamate | [174] |
miR-522 | Inhibits ferroptosis in gastric cancer | Downregulates ALOX15 | [60] |
miR-23a-3p | Inhibits ferroptosis in HCC | Downregulates ACSL4 | [54] |
miR-4443 | Inhibits ferroptosis in NSCLC | Downregulates m6A, upregulates FSP1 | [46] |
miR-424-5p | Inhibits ferroptosis in ovarian cancer | Downregulates ACSL4 | [55] |
miR-7-5p | Inhibits ferroptosis in ovarian, oral squamous cell and HCC | Downregulates mitoferrin, reduces mitochondrial iron levels | [99] |
miR-7-5p | Inhibits ferroptosis in cervical and oral squamous carcinomas | Upregulates ferritin, downregulates ALOX12 expression | [59] |
