Table 3 Examples of circRNAs implicated in ferroptosis regulation in cancer.

cIARS

Induces ferroptosis and ferritinophagy in sorafenib-treated HCC

Interacts with ALKBH5, improves Bcl-2 mRNA stability, enhances Bcl-2/BECN1 interaction

[139]

circ_0000190

Induces ferroptosis in gastric cancer

Sponges miR-382-5p, upregulates ZNRF3, inhibits Wnt/β-catenin signaling

[178]

circKDM4C

Induces ferroptosis in AML

Sponges miRNA let-7b-5p. When present, upregulates ACSL4, PTGS2 and p53, and downregulates GPX4 and FTH1

[32]

circ-TTBK2

Inhibits ferroptosis in glioma

Sponges miR-761, upregulates ITGB8 expression

[179]

circCDK14

Inhibits ferroptosis in glioma

Sponges miR-3938, upregulates PDGFRA, GPX4 and SLC7A11 expression

[30]

circKIF4A

Inhibits ferroptosis in papillary thyroid cancer

Sponges miR-1231, upregulates GPX4 expression

[146]

circ_0067934

Inhibits ferroptosis in papillary and follicular thyroid cancers

Sponges miR-545-3p, upregulates SLC7A11 expression

[144]

circDTL

Inhibits ferroptosis in NSCLC

Sponges miR-1287-5p, upregulates GPX4

[31]

circRHOT1

Inhibits ferroptosis in breast cancer

Sponges miR-106a-5p, upregulates STAT3

[180]

circGFRA1

Inhibits ferroptosis in breast cancer

Sponges miR‐1228, upregulates AIFM2 and GPX4 expression

[181]

circPVT1

Inhibits ferroptosis in esophageal cancer

Sponges miR-30a-5p, upregulates FZD3, GPX4 and SLC7A11 expression

[40]

circIL4R

Inhibits ferroptosis in HCC

Sponges miR-541-3p, upregulates GPX4 expression

[182]

circ0097009

Inhibits ferroptosis in HCC

Sponges miR-1261, upregulates SLC7A11

[143]

circABCB10

Inhibits ferroptosis in CRC

Sponges miR-326, upregulates CCL5

[141]

circ_0007142

Inhibits ferroptosis in CRC

Sponges miR-874-3p, upregulates GDPD5

[183]

circEPSTI1

Inhibits ferroptosis in cervical cancer

Sponges miR-375, miR-409-3p and miR-515-5p, upregulates SLC7A11 expression

[41]