Fig. 2: SOCS2 overexpression sensitized HCC to IR (IR) in vivo and in vitro. | Cell Death & Differentiation

Fig. 2: SOCS2 overexpression sensitized HCC to IR (IR) in vivo and in vitro.

From: SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma

Fig. 2: SOCS2 overexpression sensitized HCC to IR (IR) in vivo and in vitro.The alternative text for this image may have been generated using AI.

A Western blot assay of SOCS2 and tubulin proteins in SK-Hep-1, SK-Hep-1R, HepG2 and HepG2R cells. B, C Western blot assay of SOCS2 and tubulin proteins in SK-Hep-1 and HepG2 cells transfected with lvSOCS2, siSOCS2 or their negative control (lvNC, siNC). D Dose responses of survival factions of SK-Hep-1 and HepG2 cells with or without lvSOCS2 transfection. SK refers to SK-Hep-1, HG refers to HepG2. E Dose responses of survival factions of SK-Hep-1 and HepG2 cells with or without siSOCS2 transfection. F, G General view of tumor mass of each indicated group at 24 days after cell injection. H, I Tumor volume of above groups was examined every 3 days until 24 days after subcutaneously cell injection. J Representative immunohistochemistry images of the expressions of SOCS2, 4-HNE, GPX4 and SLC7A11 protein in the aforementioned xenograft tumors (x40). The red arrow indicated the spot or region where positive protein expression was present. Scale bars, 20 μm. *P < 0.05, **P < 0.01 and ***P < 0.001 between indicated groups.

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