Fig. 1: R312H mice exhibit anxious behavior and severe seizure phenotype. | Cell Death & Differentiation

Fig. 1: R312H mice exhibit anxious behavior and severe seizure phenotype.

From: Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

Fig. 1

A Representative pictures of a R312H heterozygote and homozygote mice showing areas of excoriated skin caused by excessive grooming, and percentage of time spent grooming per minute, per genotype (N = 8 animals/genotype). Mice were recorded with time-locked Lorex cameras and DVR. B Percentage of time spent in the center or on the sides of the arena. Mice were kept in the arena for 10 mins and were recorded using a video-tracking system. WT, HOMO, and NULL: 7 mice/group; HETERO: 6 mice. C Representative traces showing spontaneous electrographic seizures recorded from cortical electrodes from mice of the indicated genotypes. D Bar graph denotes average number of seizures per day in R312H heterozygotes (N = 5), R312H homozygotes (N = 6) and NULL (N = 6) mice. E Mean duration of seizure in seconds in R312H heterozygotes (N = 5), R312H homozygotes (N = 6) and NULL (N = 6) mice. F Mean time spent in seizures in a day in minutes in R312H heterozygotes (N = 5), R312H homozygotes (N = 6) and NULL (N = 6) mice. ***P < 0.001 and ****P < 0.0001 (one-way ANOVA, Tukey’s post hoc).

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