Fig. 8: Ang II corrects morphological defects of R312H primary cortical neurons. | Cell Death & Differentiation

Fig. 8: Ang II corrects morphological defects of R312H primary cortical neurons.

From: Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

Fig. 8

A Total dendrite length of DIV14 primary cortical neurons from the indicated genotypes, incubated in the absence/presence of 0.7 μM Ang II. N = 20 neurons/genotype, from 4 WT pups; 5 HETERO pups and 4 HOMO pups. B Mean Sholl intersection profiles of the primary neurons of the various genotypes incubated in the absence presence of 0.7 μM Ang II. Each mean SIP was obtained by averaging 20 individual SIPs from 4 WT pups; 5 HETERO pups and 4 HOMO pups. P < 0.001 for WT vs. heterozygous R312H; P < 0.001 for WT vs. homozygous R312H in control and not statistically significant (NSS) in the presence of Ang II (Kolmogorov–Smirnov test). *P < 0.05, ***P < 0.001, and ****P < 0.0001 (one-way ANOVA, Tukey’s post hoc).

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