Fig. 5: T166 phosphorylation controls fat degradation and lipid catabolism. | Cell Death & Differentiation

Fig. 5: T166 phosphorylation controls fat degradation and lipid catabolism.

From: Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions

Fig. 5

a GO analysis of differentially expressed genes among the three genotypes (n = 4). b Expression of fatty acid oxidation genes by RNA-Seq (n = 4). P < 0.05 according to an unpaired two-sided Student’s t-test and LogFC >0.5. c Volcano plot showing beige cell markers. (d) The gross appearance of adipose tissue from homozygous WT/WT, TA/TA and TD/TD mice following 3 h 4°C acute cold challenge pretreated with overnight fasting (n = 6). e The content of adipose fat pads (percentage of body weight) from WT/WT, TA/TA and TD/TD mice (n = 6). f Serum free fatty acid (FFA) and glycerin levels (n = 6). g Q-PCR analysis of lipid catabolism genes in isolated adipocytes from SATs (n = 6). Data are expressed as the mean ± S.E.M. Data were analyzed using one-way ANOVA followed by Tukey’s test (e–g). *P < 0.05. **P < 0.01, ***P < 0.001.

Back to article page