Fig. 5: Constitutively increased NF-κB activation did not affect the onset and progression of SCLC.
From: NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
A Representative images of MRI scans of Rb1FL/FL Tp53FL/FL (n = 17) and Rb1FL/FL Tp53FL/FL R26LSL.IKK2ca (n = 10) mice 26 and 32 weeks after Ad-Cre inhalation. Tumor areas were marked using Horos Software. B Graph depicting tumor onset assessed via MR imaging of mice with indicated genotypes. C Graph depicting the number of lung tumor lesions 6 weeks after Ad-Cre inhalation. Each dot represents one mouse. Mean ± SEM are shown. Mann–Whitney Test. D Graph depicting tumor fold change assessed via MR imaging 2–6 weeks after Ad-Cre inhalation for indicated genotypes. Every dot represents one mouse. Bars represent mean ± SEM. Mann–Whitney Test. E Graph depicting survival of Rb1FL/FL Tp53FL/FL and Rb1FL/FL Tp53FL/FL R26LSL.IKK2ca mice. Data from the same Rb1FL/FL Tp53FL/FL cohort are included in all figures for comparison. Log-Rank test. F Representative photographs of lungs from Rb1FL/FL Tp53FL/FL (n = 17) and Rb1FL/FL Tp53FL/FL R26LSL.IKK2ca (n = 10) mice sacrificed at the humane endpoint. G Graphs depicting the percentage of mice with liver metastasis and the amount of liver tumor lesions at the humane endpoint n = 9 for Rb1FL/FL Tp53FL/FL R26LSL.IKK2ca, n = 14 for Rb1FL/FL Tp53FL/FL. Mann–Whitney test, mean ± SEM.
