Fig. 1: MARVELD1 regulates the genotoxic stress response of cancer cells and is associated with a poor prognosis. | Cell Death & Differentiation

Fig. 1: MARVELD1 regulates the genotoxic stress response of cancer cells and is associated with a poor prognosis.

From: The regulation loop of MARVELD1 interacting with PARP1 in DNA damage response maintains genome stability and promotes therapy resistance of cancer cells

Fig. 1

a The proliferation curves of HeLa/PC and HeLa/MARVELD1 cells treated by HU, CPT or Aph for 14 days. b Immunofluorescent (IF) staining and intensity analysis of MARVELD1-V5 and γ-H2AX in HU-treated HeLa/PC and HeLa/MARVELD1 cells. c Neutral comet assays of HeLa/PC and HeLa/MARVELD1 cells treated with HU for 4 h. d The cell cycle of HeLa/PC and HeLa/MARVELD1 cells were detected at different times after HU releasement. e The endogenous MARVELD1 protein level in HeLa cells was assessed after different times or dose treatment by X-ray radiation. f The endogenous MARVELD1 mRNA level in HeLa cells was assessed after different times or dose treatment by X-ray radiation. *p < 0.05, **p < 0.01, ***p < 0.001.

Back to article page